Secondary Induction: Overview


Secondary induction is the tissue interaction governing cell differentiation and morphogenesis throughout embryonic development.

Keywords: embryonic induction; epithelial–mesenchymal interactions; competence; signal transmission; developmental options

Figure 1.

Alternation of directive and permissive inductions during development followed by gradual restriction of the developmental options.

Figure 2.

Branching pattern of the ureter‐derived epithelium in the kidney visualized by whole‐mount staining with an antibody against epithelial keratin.

Figure 3.

Strategy of the reciprocal combination of the mammary epithelium and mesenchyme from a wild‐type mouse and from an androgen‐insensitive mutant (Tfm mutant).


Further Reading

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Cunha GR, Young P, Higgins SJ and Cooke PS (1991) Neonatal seminal vesicle induces a new morphological and functional phenotype in the epithelia of adult ureter and ductus deferens. Development 111: 145–158.

Deuchar EM (1975) Cellular Interactions in Animal Development. London: Chapman & Hall.

Durnberger H and Kratochwil K (1980) Specificity of tissue interaction and origin of mesenchymal cells in the androgen response of the embryonic mammary gland. Cell 19: 465–471.

Gilbert SG (1997) Proximate tissue interaction: Secondary induction. In: Developmental Biology, 5th edn, pp. 655–699. Sunderland, MA: Sinauer Associates.

Goetinck PF and Abbott UK (1963) Tissue interaction in the scaleless mutant and the use of scaleless as an ectodermal marker in studies of normal limb development. Journal of Experimental Zoology 154: 7–19.

Grainger RM (1992) Embryonic lens induction: shedding light on vertebrate tissue determination. Trends in Genetics 8: 349–355.

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Saxén L (1977) Directive versus permissive induction: A working hypothesis. In: Lash JW and Burger MM (eds) Cell and Tissue Interactions, pp. 1–9. New York: Raven Press.

Saxén L (1987) Organogenesis of the kidney. Cambridge: Cambridge University Press.

Saxén L, Karkinen‐Jääskeläinen M, Lehtonen E, Nordling S and Wartiovaara J (1976) Inductive tissue interactions. In: Poste G and Nicolson GL (eds) The Cell Surface in Animal Embryogenesis and Development, pp. 331–407. Amsterdam: North Holland.

Sengel P and Dhouailly D (1977) Tissue interactions in amniote skin development. In: Karkinen‐Jääskeläinen M, Saxén L and Weiss L (eds) Cell Interactions in Development, pp. 145–169. London: Academic Press.

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Vainio S and Muller U (1997) Inductive tissue interactions, cell signaling, and the control of kidney organogenesis. Cell 90: 975–978.

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Saxén, Lauri(Apr 2001) Secondary Induction: Overview. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0001140]