Nonprotein‐coding Genes


In addition to the genes that encode messenger ribonucleic acids and are translated into proteins, the human genome includes hundreds to thousands of genes that encode a variety of functional ribonucleic acid (RNA) molecules. The number of known RNA species has grown rapidly in recent years and many additional examples will doubtless be found.

Keywords: tRNA; rRNA; snRNA; snoRNA; ribozyme


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Further Reading

Collins CA and Guthrie C (2000). The question remains: is the spliceosome a ribozyme? Nature Structural Biology 7: 850–854.

Eddy SR (1999) Noncoding RNA genes. Current Opinion in Genetics and Development 9: 695–699.

Erdmann VA, Barciszewska MZ, Hochberg A, de Groot N and Barciszewski J (2001) Regulatory RNAs. Cell and Molecular Life Science 58: 960–977.

Gesteland RF, Cech TR and Atkins JR (eds.) (1999) The RNA World, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

Huang Y and Maraia RJ (2001) Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human. Nucleic Acids Research 29: 2675–2690.

Kelley RL and Kuroda MI (2000) Noncoding RNA genes in dosage compensation and imprinting. Cell 103: 9–12.

Kiss T (2001) Small nucleolar RNA‐guided post‐transcriptional modification of cellular RNAs. EMBO Journal 20: 3617–3622.

Lafontaine DL and Tollervey D (2001) The function and synthesis of ribosomes. Nature Reviews of Molecular and Cell Biology 2: 514–520.

Maguire BA and Zimmermann RA (2001) The ribosome in focus. Cell 104: 813–816.

Xiao S, Houser‐Scott F and Engelke DR (2001) Eukaryotic ribonuclease P: increased complexity to cope with the nuclear pre‐tRNA pathway. Journal of Cell Physiology 187: 11–20.

Web Links

Imprinted in Prader–Willi syndrome (IPW); Locus ID: 3653. Locuslink:

RNA component of mitochondrial RNA processing endoribonuclease (RMRP); Locus ID: 6023. Locuslink:

RNA, ribosomal 1 (RNR1); Locus ID: 6052. Locuslink:

RNA, 5S cluster 1 (RN5S1@); Locus ID: 6025. Locuslink:

RNA, U1A small nuclear (RNU1A); Locus ID: 6060. Locuslink:

Imprinted in Prader–Willi syndrome (IPW); MIM number: 601491. OMIM:‐post/Omim/dispmim?601491

RNA component of mitochondrial RNA processing endoribonuclease (RMRP); MIM number: 15766. OMIM:‐post/Omim/dispmim?157660

RNA, ribosomal 1 (RNR1); MIM number: 180450. OMIM:‐post/Omim/dispmim?180450

RNA, U1A small nuclear (RNU1A); MIM number: 180680. OMIM:‐post/Omim/dispmim?180680

RNA, 5S cluster 1 (RN5S1@); MIM number: 180420. OMIM:‐post/Omim/dispmim?180420

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Tollervey, David(Sep 2005) Nonprotein‐coding Genes. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005018]