Mood Disorders: Molecular


Mood disorders are common complex genetic disorders in which the core feature is a pathological disturbance of mood ranging from extreme elation (mania) to severe depression. Large‐scale positional and candidate gene studies are ongoing and promising findings are emerging but robust confirmation is awaited.

Keywords: bipolar disorder; unipolar disorder; major depression; affective disorders; psychosis


APA (1994) Diagnostic and Statistical Manual for Mental Disorders, 4th edn. Washington, DC: American Psychiatric Association.

Baron M, Risch N, Hamburger R, et al. (1987) Genetic linkage between X‐chromosome markers and bipolar affective illness. Nature 326: 289–292.

Craddock N, Davé S and Greening J (2001) Association studies of bipolar disorder. Bipolar Disorders 3: 284–298.

Curtis D (1999) Chromosome 21 workshop. American Journal of Medical Genetics 88: 272–275.

Detera‐Wadleigh SD (1999) Chromosomes 12 and 16 workshop. American Journal of Medical Genetics 88: 255–259.

Egeland JA, Gerhard DS, Pauls DL, et al. (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325: 783–787.

Kennedy JL, Basile VA and Macciardi FM (1999) Chromosome 4 workshop summary. American Journal of Medical Genetics 88: 224–228.

Van Broeckhoven C and Verheyen G (1999) Report of the chromosome 18 workshop. American Journal of Medical Genetics 88: 263–270.

World Congress of Psychiatric Genetics (1999) Chromosome workshop summaries. American Journal of Medical Genetics (Neuropsychiatric Genetics) 88(3) [whole issue].

Further Reading

Barondes SH (1998) Mood Genes. Hunting for Origins of Mania and Depression. Harmondsworth, UK: Penguin.

Charney DS, Nestler EJ and Bunney BS (eds.) (1999) Neurobiology of Mental Illness Oxford, UK: Oxford University Press.

Craddock N and Jones I (1999) Genetics of bipolar disorder. Journal of Medical Genetics 36: 585–594.

Farmer AE, Williams J and Jones I (1994) Phenotypic definitions of psychotic illness for molecular genetic research. American Journal of Medical Genetics (Neuropsychiatric Genetics) 54: 365–371.

Goodwin FK and Jamison KR (1990) Manic‐Depressive Illness. Oxford, UK: Oxford University Press.

Malhi GS, Moore J and McGuffin P (2000) The genetics of major depressive disorder. Current Psychiatry Reports 2: 165–169.

McGuffin P, Owen MJ, O'Donovan MC, Thapar A and Gottesman II (1994). Seminar in Psychiatric Genetics. London, UK: Gaskell.

Paykel ES (ed.) (1992) Handbook of Affective Disorders,. 2nd edn. Edinburgh, UK: Churchill Livingstone.

Soares JC and Gershon S (eds.) (2000) Bipolar Disorders. Basic Mechanisms and Therapeutic Implications. New York, NY: Marcel Decker.

Sullivan PS, Neale MC and Kendler KS (2000) Genetic epidemiology of major depression: review and meta‐analysis. American Journal of Psychiatry 157: 1552–1562.

Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

How to Cite close
Craddock, Nick, Jones, Ian, and Kent, Lindsey(Jul 2006) Mood Disorders: Molecular. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005161]