Model‐based Linkage Analysis


Model‐based linkage analysis is the analysis of the cosegregation of genetic loci in pedigrees. The most common form of linkage analysis uses pedigrees selected due to the presence of individuals affected by a disease that is assumed or known to have a major genetic component. Genetic markers are then examined to identify loci that appear to be cotransmitted with the predisposing disease locus.

Keywords: lod scores; parametric linkage analysis; genetic heterogeneity; genetic linkage analysis

Figure 1.

Pedigree segregating a known recessive disease (see text for explanation). Open circles: unaffected females; open squares: unaffected males; full circles: affected females; full squares: affected males; D: disease‐causing allele at disease locus; d: wild‐type allele at disease locus. A, B, C and D are four distinct alleles at the genetic marker. The meiotic phase is known.



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Further Reading

Terwilliger JD and Ott J (1994) Handbook of Human Genetic Linkage. Baltimore, MD: Johns Hopkins University Press.

Web Links Rockefeller University: Web resources of genetic linkage analysis. This website contains an up‐to‐date list of available genetic analysis software packages and links to download instructions

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Teare, Marion Dawn(Jul 2006) Model‐based Linkage Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005401]