Development: Disorders


Development is the process leading to completely differentiated tissues an organs derived from a single fertilized egg. Many advances have been made toward understanding the molecular and biological basis of the cellular events involved in normal development, which allow us to foresee the classification of genetic and acquired disorders of development.

Keywords: development; organogenesis; brain development; homeotic genes; cell migration


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Feng Y, Olson EC, Stukenberg PT, et al. (2000) LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron 28: 665–679.

Liu Z, Steward R and Luo L (2000) Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. Nature Cell Biology 2: 776–783.

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Reiner O, Carrozzo R, Shen Y, et al. (1993) Isolation of a Miller‐Dieker lissencephaly gene containing G protein beta‐subunit‐like repeats. Nature 364: 717–721.

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Further Reading

Boncinelli E, Mallamaci A and Broccoli V (1998) Body plan genes and human malformation. Advances in Genetics 38: 1–29.

McGinnis W and Krumlauf R (1992) Homeobox genes and axial patterning. Cell 68: 283–302.

Nanni L, Schelper RL and Muenke M (2000) Molecular genetics of holoprosencephaly. Frontiers in Bioscience 5: 334–342.

Reiner O (2000) LIS1: let's interact sometimes… (part 1). Neuron 28: 633–636.

Vallee RB, Tai C and Faulkner NE (2001) LIS1: cellular function of a disease‐causing gene. Trends in Cell Biology 11: 155–160.

Web Links

Empty spiracles homolog 2 (Drosophila) (EMX2); Locus ID: 2018. LocusLink:

Orthodenticle homolog 1 (Drosophila) (OTX1); Locus ID: 5013. LocusLink:

Paired box gene 2 (PAX2); Locus ID: 5076. LocusLink:

Sonic hedgehog homolog (Drosophila) (SHH); Locus ID: 6469. LocusLink:

TGFB‐induced factor (TALE family homeobox) (TGIF); Locus ID: 7050. LocusLink:

Empty spiracles homolog 2 (Drosophila) (EMX2); MIM number: 600035. OMIM:‐post/Omim/dispmim?600035

Orthodenticle homolog 1 (Drosophila) (OTX1); MIM number: 600036. OMIM:‐post/Omim/dispmim?600036

Paired box gene 2 (PAX2); MIM number: 167409. OMIM:‐post/Omim/dispmim?167409

Sonic hedgehog homolog (Drosophila) (SHH); MIM number: 600725. OMIM:‐post/Omim/dispmim?600725

TGFB‐induced factor (TALE family homeobox) (TGIF); MIM number: 602630. OMIM:‐post/Omim/dispmim?602630

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How to Cite close
Carrozzo, Romeo, and Boncinelli, Edoardo(Jan 2006) Development: Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005507]