Hematopoietic Stem Cells


Hematopoietic stem cells are the common ancestor to every type of blood cell. They undergo massive proliferation and differentiation to produce billions of red blood cells, white blood cells and platelets.

Keywords: blood; hematopoietic stem cell; transplantation

Figure 1.

Hematopoiesis and gene transduction. Pluripotent hematopoietic stem cells undergo self‐renewal or commitment to differentiation under the influence of hematopoietic growth factors produced from the bone marrow stromal cells (e.g. interleukin‐6 (IL‐6), (SCF), granulocyte–monocyte colony stimulating factor (GM‐CSF), flt‐3 ligand (FL) and (TPO)). Progenitor cells proliferate and differentiate along pathways of increasingly restricted developmental potential to produce mature blood cells. CFU‐GM: granulocyte–monocyte colony‐forming unit; CFU‐GEMM: granulocyte–erythrocyte–monocyte–megakaryocyte colony‐forming unit; BFU‐E: burst‐forming unit‐erythroid.



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Further Reading

Civil CI (1990) Mini‐review: human monomyeloid cell membrane antigens. Experimental Hematology 18: 461–467.

Goldman J (1998) Hematopoietic stem cell transplantation. Current Opinion in Hematology 5: 417–418.

Greenberg PD and Riddell SR (1999) Deficient cellular immunity – finding and fixing the defects. Science 285: 546–551.

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Metcalf D (1998) Regulatory mechanisms controlling hematopoiesis: principles and problems. Stem Cells 16(supplement 1): 3–11.

Murphy WJ and Blazar BR (1999) New strategies for preventing graft‐versus‐host disease. Current Opinion in Immunology 11: 509–515.

Orkin SH (1996) Development of the hematopoietic system. Current Opinion in Genetics and Development 6: 597–602.

Parkman R (1986) The application of bone marrow transplantation to the treatment of genetic diseases. Science 232: 1373–1378.

Weissman IL (2000) Stem cells: units of development, units of regeneration, and units in evolution. Cell 100: 157–168.

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Kohn, Donald B, Nolta, Jan A, and Crooks, Gay M(Jan 2006) Hematopoietic Stem Cells. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005764]