Integrins are transmembrane αβ heterodimeric receptor complexes involved in diverse pathophysiological processes by mediating cell adhesion and migration. Integrin–ligand interaction and postligand binding functions of integrins are regulated by intracellular signaling mechanisms.

Keywords: adhesion; migration; extracellular matrix; cytoskeleton; signaling

Figure 1.

Schematic representation of an integrin αβ heterodimer. SS in the α subunit represents the disulfide bond connecting the heavy and light chains.

Figure 2.

The integrin family members. Pairings of integrin α and β subunits are illustrated.



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Further Reading

Calderwood DA, Shattil SJ and Ginsberg MH (2000) Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. Journal of Biological Chemistry 275: 22607–22610.

Critchley DR (2000) Focal adhesions: the cytoskeletal connection. Current Opinion in Cell Biology 12: 133–139.

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Hynes RO (2002) Integrins: bidirectional allosteric signaling machines. Cell 110: 673–687.

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Woods A and Couchman JR (2000) Integrin modulation by lateral association. Journal of Biological Chemistry 275: 24233–24236.

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Lam, Stephen C‐T, and Loftus, Joseph C(Jan 2006) Integrins. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005910]