Noncoding RNAs: A Regulatory Role?


Around 97–98% of the transcriptional output of the human genome is noncoding RNA, which is derived from noncoding RNA genes and from introns in protein‐coding genes. These RNAs may form a higher‐order regulatory network that integrates complex suites of gene activity during differentiation and development.

Keywords: introns; eRNA; RNA interference; intergenic; processing


Clement JQ, Maiti S and Wilkinson MF (2001) Localization and stability of introns spliced from the Pem homeobox gene. Journal of Biological Chemistry 276: 16919–16930.

Eddy SR (2001) Non‐coding RNA genes and the modern RNA world. Nature Reviews Genetics 2: 919–929.

Grishok A, Pasquinelli AE, Conte D, et al. (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106: 23–34.

Kapranov P, Cawley SE, Drenkow J, et al. (2002) Large‐scale transcriptional activity in chromosomes 21 and 22. Science 296: 916–919.

Lander ES, Linton LM, Birren B, et al. (2001) Initial sequencing and analysis of the human genome. Nature 409: 860–921.

Mattick JS (1994) Introns: evolution and function. Current Opinion in Genetics and Development 4: 823–831.

Mattick JS (2001) Non‐coding RNAs: the architects of eukaryotic complexity. EMBO Reports 2: 986–991.

Mattick JS and Gagen MJ (2001) The evolution of controlled multitasked gene networks: the role of introns and other noncoding RNAs in the development of complex organisms. Molecular Biology and Evolution 18: 1611–1630.

Okazaki Y, Furuno M, Kasukawa T, et al. (2002) Analysis of the mouse transcriptome based upon functional annotation of 60,770 full length cDNAs. Nature 420: 563–573.

Ruvkun G (2001) Glimpses of a tiny RNA world. Science 294: 797–799.

Venter JC, Adams MD, Myers EW, et al. (2001) The sequence of the human genome. Science 291: 1304–1351.

Zhuo D, Zhao WD, Wright FA, et al. (2001) Assembly, annotation, and integration of UNIGENE clusters into the human genome draft. Genome Research 11: 904–918.

Further Reading

Akhtar A, Zink D and Becker PB (2000) Chromodomains are protein–RNA interaction modules. Nature 407: 405–409.

van Hoof A and Parker R (1999) The exosome: a proteasome for RNA? Cell 99: 347–350.

Hüttenhofer A, Kiefmann M, Meier‐Ewert S, et al. (2001) RNomics: an experimental approach that identifies 201 candidates for novel, small, non‐messenger RNAs in mouse. EMBO Journal 20: 2943–2953.

Lagos‐Quintana M, Rauhut R, Lendeckel W and Tuschl T (2001) Identification of novel genes coding for small expressed RNAs. Science 294: 853–858.

Lau NC, Lim LP, Weinstein EG and Bartel DP (2001) An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294: 858–862.

Shabalina SA, Ogurtsov AY, Kondrashov VA and Kondrashov AS (2001) Selective constraint in intergenic regions of human and mouse genomes. Trends in Genetics 17: 373–376.

Sharp PA (2001) RNA interference‐2001. Genes & Development 15: 485–490.

Tycowski KT, Shu MD and Steitz JA (1996) A mammalian gene with introns instead of exons generating stable RNA products. Nature 379: 464–466.

Vanhee‐Brossollet C and Vaquero C (1998) Do natural antisense transcripts make sense in eukaryotes? Gene 211: 1–9.

Wassenegger M (2000) RNA‐directed DNA methylation. Plant Molecular Biology 43: 203–220.

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How to Cite close
Mattick, John Stanley(Jan 2006) Noncoding RNAs: A Regulatory Role?. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005985]