Thrifty Genotype Hypothesis and Complex Genetic Disease


Thrifty genes might be responsible for the appearance and increasing frequency of diseases that were uncommon before the emergence of the affluent Western life style. Evolutionary selection of such genes enabled metabolic adaptation to disadvantageous conditions, but now thrifty gene expression is detrimental to health.

Keywords: modern old‐age diseases; polygenic diseases; metabolism; diabetes; obesity


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Vardi, Pnina, and Bloch, Konstantin(Mar 2008) Thrifty Genotype Hypothesis and Complex Genetic Disease. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0006077.pub2]