Hair Loss: Genetics


Hair formation is a complex molecular process, and abnormal hair is a feature of many genetic disorders. There is increasing understanding of the molecular basis of several single‐gene disorders with hair loss, although the genetic basis for the commonest forms of hair loss is not well understood.

Keywords: skin disorder; genodermatoses; epidermis; dermis; dermatology


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Hardy MH (1992) The secret life of the hair follicle. Trends in Genetics 8: 55–61.

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Zonana J, Elder ME, Schneider LC, et al. (2000) A novel X‐linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK‐gamma (NEMO). American Journal of Human Genetics 67: 1555–1562.

Web Links

ATP7A (ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)); Locus ID: 538. LocusLink:

EDAR (ectodysplasin 1, anhidrotic receptor); Locus ID: 10913. LocusLink:

GJB6 (gap junction protein, beta 6 (connexin 30)); Locus ID: 10804. LocusLink:

JUP (junction plakoglobin); Locus ID: 3728. LocusLink:

ATP7A (ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)); MIM number: 300011. OMIM:‐post/Omim/dispmim?300011

EDAR (ectodysplasin 1, anhidrotic receptor); MIM number: 604095. OMIM:‐post/Omim/dispmim?604095

GJB6 (gap junction protein, beta 6 (connexin 30)); MIM number: 604418. OMIM:‐post/Omim/dispmim?604418

JUP (junction plakoglobin); MIM number: 173325. OMIM:‐post/Omim/dispmim?173325

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How to Cite close
Irvine, Alan(Jan 2006) Hair Loss: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0006103]