Transcriptional Regulation: Evolution


Changes in transcriptional regulation can result from mutations in cis (within regulatory sequences) or trans (in the structure or expression of transcription factors). Modifications in transcription can have a profound impact on gene function and constitute an important class of evolutionary change within genomes.

Keywords: cis‐regulatory sequence; enhancer; polymorphism; promoter; transcription factor


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Wray, Gregory A(Dec 2007) Transcriptional Regulation: Evolution. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0006142.pub2]