deCODE: A Genealogical Approach to Human Genetics in Iceland


The identification of genes contributing to diseases provides the most direct method for discovering the rate‐limiting molecular pathways involved in their pathogenesis. deCODE has built a system of information in Iceland, linking medical information from patients who have given them specific informed consent, disease by disease, to a nation‐wide genealogy database and their molecular genetic information.

Keywords: genealogy; Iceland; genetics; common disease; genotype


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Further Reading

Gretarsdottir S, Thorleifsson G, Reynirsdottir S, et al. Phosphodiesterase 4D gene polymorphisms confer risk to ischemic stroke (submitted).

Styrkarsdottir U, Cazier JB, Rolfsson O, et al. The Bone Morphogenetic Protein 2 gene contributes to bone mass density and osteoporotic fractures (submitted).

Web Links

deCODE genetics. Website for Decode Genetics describing the company, the diseases of interest and population based genetics platform

BMP2 (bone morphogenetic protein 2); Locus ID: 650. LocusLink:

NRG1 (neuregulin 1); Locus ID: 3084. LocusLink:

PDE4D (phosphodiesterase 4D, cAMP‐specific (phosphodiesterase E3 dunce homolog, Drosophila)); Locus ID: 5144. LocusLink:

BMP2 (bone morphogenetic protein 2); MIM number: 112261. OMIM:‐post/Omim/dispmim?112261

NRG1 (neuregulin 1); MIM number: 142445. OMIM:‐post/Omim/dispmim?142445

PDE4D (phosphodiesterase 4D, cAMP‐specific (phosphodiesterase E3 dunce homolog, Drosophila)); MIM number: 600129. OMIM:‐post/Omim/dispmim?600129

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How to Cite close
Gulcher, Jeffrey R, and Stefansson, Kari(Sep 2006) deCODE: A Genealogical Approach to Human Genetics in Iceland. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0006270]